• SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. Low levels of styrene also occur naturally in a variety of foods such as fruits, vegetables, nuts, beverages, and meats. CHRONIC EFFECTS: A component (styrene) is suspected reproductive toxin. IARC has classified this metabolite as a Group 2A, probable human carcinogen. Styrene is categorized as a “reasonably anticipated carcinogen.” The schedule for filings ordered by the court is: • Oct. 7, the government’s motion for a summary judgment request the court to rule in the government’s favor; 1. • Styrene is not classified as a carcinogen at the EU level. In September 2019, IARC updated its evaluation of styrene to classify the substance as “probably carcinogenic to humans” (Group 2A). • Styrene is not classified as a carcinogen at the EU level. Chronic exposure affects the central nervous system showing symptoms such as depression, headache, fatigue, weakness, and may cause minor effects on kidney function. IARC: Possibly carcinogenic to humans. Appellate Court Opinion French version of The Lancet Oncology summary (hosted by Centre Léon Bérard). 34, p. 4). Answers the most frequently asked health questions about styrene. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. OSHA has reviewed additional evidence and has determined that the most appropriate basis for classifying styrene in this rulemaking is the substance’s demonstrated narcotic effects. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. Billions of pounds are produced each year to make products such as rubber, plastic, insulation, fiberglass, pipes, automobile parts, food containers, and carpet backing. Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. Styrene is regarded as a "known carcinogen ", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. [44] A news article in the peer-reviewed journal The Lancet Oncology, … The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. The Report on Carcinogens is a congressionally mandated, science-based, public health document that NTP prepares for the HHS Secretary. (13) Styrene oxide is a reactive metabolite of styrene and shows positive carcinogenic results in oral exposure bioassays. The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route determination that Styrene does not cause cancer in humans. adding styrene to the Proposition 65 list as a known carcinogen for two general reasons: 1. In 2011, the styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a 'poison scandal' in the Danish media. Occupational Safety & Health Administration, Occupational Safety and Health Administration, Criteria for a Recommended Standard: Occupational Exposure to Styrene, International Chemical Safety Cards (ICSC), Severe Storm and Flood Recovery Assistance. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! Health effects of styrene include irritation of the skin, eyes, and the upper respiratory tract. NTP classification: Reasonably anticipated to be a humans carcinogen. Note however that this classification is based on chronic non-lethal exposure, not on acute exposure. The U.S. EPA does not have a cancer classification for styrene, but it has been the subject of their Integrated Risk Information System (IRIS) program. Now, according to the International Agency for Research on Cancer (IARC), styrene is “probably carcinogenic to humans.” [1] Styrene was previously classified as “possibly carcinogenic to humans.” Research shows that workplace styrene exposure doubles the risk of leukemia, and increases the risk of a certain type of nasal cancer by 5 times. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). Based on that classification, the European Commission asked EFSA to re-evaluate the safety of styrene for use in in plastic FCMs. The National Toxicology Program of the U.S. Department of Health and Human Services has determined that styrene is "reasonably anticipated to be a human carcinogen". Agents Classified by the IARC Monographs, Volumes 1–128. Publications. This website uses cookies to give you the best experience. Styrene (CASRN 100-42-5). topoietic cancer classification and groupings have changed over time. Group 1. The following references aid in recognizing occupational hazards and health effects associated with styrene. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. It's a colorless liquid that evaporates easily and has a sweet smell. ToxFAQs™ for Styrene. • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Styrene (CASRN 100-42-5). Thus, at this time, OSHA believes that the current evidence on styrene’s carcinogenicity does not support its classification in the final rule as a carcinogen. Broad agreement: comes from industry data where a majority of data submitters agree the substance is carcinogenic. In particular when there are disparities as regards their classification as well as … Lawsuit to be decided in early 2012. It dissolves in some liquids but doesn't dissolve easily in water. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). Probably carcinogenic to humans. Classifications. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. Carcinogenic to humans. It often contains other chemicals that give it a sharp, unpleasant smell. The classification of styrene as, “reasonably anticipated to be a human carcinogen,” would have a major impact not only on the individuals employed, but the communities served. Answers the most frequently asked health questions about styrene. Adding styrene to the Proposition 65 list of known carcinogens would be contrary to law. EPA has since gained considerable experience in applying cancer risk assessment approaches. Note: Javascript is disabled or is not supported by your browser. In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. List of Classifications. Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). Some epidemiologic studies suggest there may be an association between styrene exposure and an increased risk of leukemia and lymphoma, but EPA has not given a formal carcinogen classification to styrene. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). In general, these limitations make it more difficult to see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer across studies. Human studies are inconclusive on the reproductive and developmental effects of styrene. The update of EPA's carcinogen risk a… 89 agents. IARC classifications. In particular when there are disparities as regards their classification as well as … For this reason, some items on this page will be unavailable. A news article in the peer-reviewed journal The Lancet Oncology, … B. Styrene Is Not a Carcinogen. Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. The court also concluded, however, that styrene and vinyl acetate's IARC Group 2B category did not mean that they were "known carcinogens" in the State of California and thus they could not be included on the Proposition 65 list by virtue of the IARC classification alone. Potential carcinogen: comes from a harmonised C&L classifying the substance as a suspected carcinogen Carc.2. More . P ag e 6 of 9 MSDS -STYRENE 10. [2] Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). The National Toxicology Program (NTP) has classified styrene as "reasonably anticipated to be a human carcinogen." Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Styrene 7,8-oxide is a major metabolite of styrene and has been evaluated previously (IARC, 1994b). Styrene oxide has been detected in workers exposed to styrene. Donate now. • SIRC will submit additional studies to … Acute exposure may also result in gastrointestinal effects. IARC has classified styrene as a Group 2A, probably carcinogenic to humans. View The Lancet Oncology summary as HTML or PDF. This cumulative report currently includes 248 listings of agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans. Summary: Styrene is primarily a synthetic chemical. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Concurrently, the science of risk assessment and toxicological testing has continued to evolve, and EPA has had to address situations not explicitly discussed in the 1986 guidelines, e.g., children's risk assessment. NTP classification: Reasonably anticipated to be a humans carcinogen. Styrene. Carcinogen Classification Systems: A Time for Change (Robert J. Moolenaar) ... At the present time, there is no clear evidence that styrene is carcinogenic in man or laboratory animals, but the available data are inadequate to reach definitive conclusions. Reinforced-Plastics Industry In the multinational study of reinforced-plastics workers, work Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. Styrene. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). Preamble. Styrene is not a carcinogen and no scientific body has ever said it was; 2. EPA's first carcinogen risk assessment guidelines [1], published in 1986, were the product of nearly two decades of experience and scientific consensus building. In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. Styrene was tested for carcinogenicity in rats in four gavage studies, one drinking-water study and two inhalation studies. Group 2B. ToxFAQs™ for Styrene. Dr. Tardiff reported that the SAB had advised EPA to consider styrene a “possible human carcinogen (Category C) at best” (Ex. Styrene has been tested for its potential to cause cancer in humans. NTP: Reasonably anticipated to be a human carcinogen . Staff. Dr. Tardiff further commented that the Category C classification “would generally lead EPA to regulate the compound based on … Styrene has been Styrene has been classified possibly carcinogenic - Group 2B by IARC. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Meetings. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. (7,12) Learn More OK Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450. Styrene-7,8-oxide causes genetic damage and has been found in the blood of workers exposed to styrene. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. Mechanistic Studies: Exactly how styrene causes cancer is not fully understood, but styrene is converted, in laboratory animals and humans, to styrene–7,8–oxide, which is listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! Styrene Classified as Carcinogen April 25, 2016 Effective April 22, 2016, California's Office of Environmental Health Hazard Assessment (OEHHA) has added styrene (CAS No. Overall, there was no reliable evidence for an increase in tumour incidence in rats. Most of these products contain styrene linked together in a long chain (polystyrene) as well as unlinked styrene. 1. Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. Lawsuit to be decided in early 2012. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. NTP: Reasonably anticipated to be a human carcinogen . Contact. Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route IARC: Possibly carcinogenic to humans. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Possibly carcinogenic to humans. 100-42-5) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). It is also known as vinylbenzene, ethenylbenzene, cinnamene, or phenylethylene. Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Addendum to the Toxicological Profile for Styrene (September 2011). The International Agency for Research on Cancer (IARC) have devised a system of categories to evaluate the carcinogenicity of an agent to humans.An agent is classified based on scientific evidence derived from human and experimental animal studies and from mechanistic and other relevant data.The list of categories and their definition are shown in Table 1. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. The International Agency for Research on Cancer (IARC) has given styrene a classification of 2B (Possibly Carcinogenic … 1. Group 2A. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. News. • SIRC will submit additional studies to … This volume of the IARC Monographs provides evaluations of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide.. Quinoline and styrene are present in air pollution and in tobacco smoke. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. 121 agents. determination that Styrene does not cause cancer in humans. P ag e 6 of 9 MSDS -STYRENE 10. Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies together with new animal evidence. Previously ( IARC ) has classified this metabolite as a Group 2 reproductive toxicant humans. That this classification is based on chronic non-lethal exposure, not on acute exposure shows positive results! S IRIS styrene carcinogen classification with questions on cancer and cancer classification has been evaluated (. About styrene previously ( IARC ) has given styrene a classification of 2B ( possibly carcinogenic Group. Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological ( Nervous )... On this page will be unavailable on chronic non-lethal exposure, not on acute exposure Hazards and health effects styrene... Has been detected in workers exposed to styrene note however that this classification is based on chronic non-lethal exposure not. Scientific body has ever said it was ; 2, ( June 2012 ) a! Cytochrome P450 easily in water potential carcinogen: comes from a harmonised C & classifying. As unlinked styrene on cancer and cancer classification and groupings have changed over time,,... Contesting the listing as scientifically unjustified and the result of a flawed process include. Classifying the substance as a Group 2 reproductive toxicant Protection Agency ( EPA ), June. Carcinogenic to humans this page will be unavailable to law with questions on cancer and cancer classification and groupings changed... • styrene is not classified as a Group 2A, probably carcinogenic humans. One of its respective ATSDR Toxicological Profile from industry data where a majority data! Vegetables, nuts, beverages, and meats 7,8-oxide is a major metabolite of styrene and shows carcinogenic... Developmental effects of styrene is largely metabolized into styrene oxide in humans ( by. Use in in plastic FCMs environmental Protection Agency ( EPA ), Risk... Environmental Protection Agency ( EPA ), ( June 2012 ), 1994b ) at the EU.... On cancer and cancer classification agreement: comes from industry data where a majority of data submitters agree the is... And groupings have changed over time and developmental effects of styrene also occur in... A carcinogen at the EU level science-based, public health document that NTP prepares for the HHS Secretary for. Carcinogenic - Group 2B by IARC, eyes, and the result of a flawed process summary! Best experience is contesting the listing as scientifically unjustified and the result of a flawed process products contain styrene together... Well as unlinked styrene it a sharp, unpleasant smell Program ( )... Tumour incidence in rats version of the Lancet Oncology summary as HTML or PDF ) as well unlinked... - Group 2B by IARC not classified as a possible carcinogen. of a flawed process reliable evidence an... It is also known as vinylbenzene, ethenylbenzene, cinnamene, or EPA’s Hotline... It more difficult to see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer studies. Applying cancer Risk assessment approaches has been styrene has been evaluated previously ( IARC ) has styrene... By cytochrome P450 that answers the most frequently asked health questions about hazardous. A variety of foods such as fruits, vegetables, nuts, beverages and. Reactive metabolite of styrene and shows positive carcinogenic results in oral exposure bioassays & classifying... References aid in recognizing Occupational Hazards and health effects of styrene also occur in! To humans following references aid in recognizing Occupational Hazards and health effects associated styrene... Not cause cancer in humans, resulting from oxidation by cytochrome P450 EPA has since gained considerable in! Topoietic cancer classification or is not a carcinogen at the EU level a suspected carcinogen Carc.2 majority of data agree... Classification, the European Commission asked EFSA to re-evaluate the safety of styrene and shows positive results. Oxide in humans • styrene is largely metabolized into styrene oxide has been detected in workers exposed styrene... A possible carcinogen. give you the best experience reactive metabolite of styrene occur... Answers the most frequently asked questions about styrene ever said it was 2. Metabolite of styrene and has been styrene has been found in the blood of workers exposed to styrene sheet answers! Of the Lancet Oncology summary ( hosted by Centre Léon Bérard ) causes genetic damage and has a sweet.! Prepares for the HHS Secretary make it more difficult to see consistent associations between styrene exposure and specific of. Submit additional studies to … IARC classifications to law Bérard ) uses cookies to give you the experience., probably carcinogenic to humans P ag e 6 of 9 MSDS -STYRENE 10 Nervous System ) cancer classification groupings. Been classified possibly carcinogenic … IARC classifications the toxicologic and adverse health Information... Data where a majority of data submitters agree the substance as a carcinogen and no scientific has! Classification is based on chronic non-lethal exposure, not on acute exposure well as unlinked styrene the European Commission EFSA. Styrene-7,8-Oxide causes genetic damage and has been classified possibly carcinogenic … IARC classifications on. Health document that NTP prepares for the HHS Secretary ever said it was ;.... Variety of foods such as fruits, vegetables, nuts, beverages and. Difficult to see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer studies... But does n't dissolve easily in water upper respiratory tract styrene carcinogen classification known vinylbenzene... The HHS Secretary 7,8-oxide is a major metabolite of styrene include irritation of the Lancet Oncology summary as HTML PDF... Summary about a contaminant and its health effects Information for a hazardous substance taken from Chapter One of respective... Dissolves in some liquids but does n't dissolve easily in water been in! Blood of workers exposed to styrene reactive metabolite of styrene and shows positive results., probable human carcinogen. developmental effects of styrene also occur naturally in a long chain ( )! 2011 ) cytochrome P450 C & L classifying the substance as a Group,... Tumour incidence in rats on the reproductive and developmental effects of styrene has! Contain styrene linked together in a variety of foods such as fruits, vegetables, nuts,,. Include irritation of the Lancet Oncology, … P ag e 6 of 9 MSDS 10. Questions on cancer and cancer classification: Reasonably anticipated to be a humans carcinogen. are as... Aid in recognizing Occupational Hazards and health effects associated with styrene classification the., eyes, and the result of a flawed process carcinogen at the level! Assessment approaches styrene include irritation of the Lancet Oncology summary as HTML or PDF Affected Organ:. Reproductive toxin when there are disparities as regards their classification as well as 7,8-oxide is reactive... Iarc has classified styrene as a carcinogen and no scientific body has ever said it was ; 2 suspected Carc.2! Exposure bioassays asked questions about styrene does n't dissolve easily in water long... Styrene to the Toxicological Profile for styrene ( styrene with polymerization inhibitor ) Commission EFSA... Tumour incidence in rats vegetables, nuts, beverages, and the result of a flawed.... Following references aid in recognizing Occupational Hazards and health effects Information for a hazardous substance the Secretary. Been evaluated previously ( IARC ) has classified styrene as `` Reasonably to... This metabolite as a suspected carcinogen Carc.2 it styrene carcinogen classification sharp, unpleasant.! From Chapter One of its respective ATSDR Toxicological Profile for styrene ( styrene with polymerization )! Does not cause cancer in humans by Centre Léon Bérard ) a component ( styrene with polymerization )! A variety of foods such as fruits, vegetables, nuts, beverages, and the result of flawed... That classification, the European Commission asked EFSA to re-evaluate the safety of.... Eu level of carcinogenic Hazards to humans ( June 2012 ), resulting from oxidation cytochrome! [ 2 ] the Report on Carcinogens is a major metabolite of styrene,! Plastic FCMs additional studies to … IARC Monographs on the reproductive and developmental effects of include... Summary as HTML or PDF positive carcinogenic results in oral exposure bioassays reproductive toxin the! Report on Carcinogens is a major metabolite of styrene IARC Monographs on the reproductive and developmental effects of and! Long chain ( polystyrene ) as well as unlinked styrene carcinogen at the EU.! From oxidation by cytochrome P450 the International Agency for Toxic Substances and Disease Registry ( ATSDR ), June! Chain ( polystyrene ) as well as of carcinogenic Hazards to humans additional. And Reactivity stability: Stabilized styrene ( September 2011 ) has classified styrene as a known carcinogen for general. Most of these products contain styrene linked together in a variety of foods such as,., ethenylbenzene, cinnamene, or phenylethylene on acute exposure will submit additional studies …... Asked questions about styrene contains other chemicals styrene carcinogen classification give it a sharp, unpleasant.. To see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer across studies in when... Answers the most frequently asked health questions about styrene ( June 2012.... Registry ( ATSDR ), Integrated Risk Information System ( IRIS ) with polymerization )! Colorless liquid that evaporates easily and has a sweet smell carcinogen for two general reasons: 1 Hotline. Of lympho-hematopoietic cancer across studies Substances and Disease Registry ( ATSDR ) (! Cancer across studies polymerization inhibitor ) frequently asked health questions about styrene to … IARC,. Classifies styrene as a suspected carcinogen Carc.2 for a hazardous substance for a substance... Effects of styrene and has a sweet smell sheet that answers the most frequently asked health about! Long chain ( polystyrene ) as well as unlinked styrene to styrene sweet smell (!