Memantine for late‐life depression and apathy after a disabling medical event: a 12‐week, double‐blind placebo‐controlled pilot study † Eric J. Lenze Department of Psychiatry, Washington University, St. … In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. Sourcing drugs is NOT allowed here! I have a few questions regarding its effects however. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. I'm sure I'm going to miss more information I wanted to put in here that might be relevant to new users so feel free to ask me anything and I'll get back to you and update this as soon as I can. If you over shoot it, it's a very long time to endure it. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. Due to the long half-life of Memantine, it could mean several more days of misery for me if my experiment doesn't pan out. Many nootropics with the very best proof and also noteworthy impact come from natural herbs, amino acids, vitamins, and also other natural materials. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Not using is always safer. Just remember that there is no 100% safe drug use. Treatment should only be continued if beneficial effects are seen. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. I am sure my nACh receptors are quite upregulated, but when I quit opoids, if I keep them upregulated (via Nicotine), I am absolutely miserable. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Thanks again dude. Its a great tool for restoring brain chemistry and resetting accumulated drug tolerances. I take the nicotine as lozenges to counteract the sedation from the opiates. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. I wish you the best in your w/d man. While I am fairly confident that Memantine will help with opioid withdrawals from what I have read, I am more concerned with its "Nicotine mimetic effects". Cerestat, IC 50 1.7 (−1; +2) μ M, was more potent than memantine, IC 50 5 (−3;+8) μ M, and the effects of both drugs were fully and rapidly reversible. How often do you use Memantine for depression? Never heard of this drug before. By using our Services or clicking I agree, you agree to our use of cookies. Looks like you're using new Reddit on an old browser. Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. What about just using NAC instead? Mine does shortly up to the point I'm about to make as well, so no judgment. While you're correct in stating that Memantine is an antagonist and that nicotine receptors upregulate in the presence of agonists or antagonists, your understanding of the chemistry of these neurotransmitters stops there. The phenyl ring of RTI-111 is substituted at R3 and R4with chlorine groups. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. It is produced as a hydrochloride salt in its powdered form. I always use Nicotine with my Opioids, and never just take one or the other. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. By blocking NMDA receptors, mema… And personally I enjoy it a lot. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. Structures and voids are very apparent in low light and I would argue go beyond level 4. You’ll notice in the categories above that some nootropics work in multiple areas of cognitive enhancement.This means fewer nootropics in a well-rounded stack.. And once you dive into the neuroscience behind each nootropic, you’ll find synergy with how many of these ingredients work together.This may result in smaller doses of each for a bigger benefit. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. So in a way it will only help you out. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. Dosing Memantine is simple, but requires some planning and forethought. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. My question is, will the nicotinic antagonistic properties of Memantine make me feel worse during my Nicotine/Opioid withdrawal - in a similar way that Nicotine by itself does? With that being said, I don't think memantine would be an enjoyable experience for everyone. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. i'm not bipolar but always had cyclothymia, adhd & anxiety. Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Duration is manageable with correct dose amount and timing. Memantine is voltage-dependent antagonist of nicotinic receptor. Functional enough to play games like Overwatch and keep up with it without any struggle. New comments cannot be posted and votes cannot be cast. Whereas on DXM, it might be too hard to try to play a game. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. Take care and go up slowly on the memantine. Visually fairly similar to ketamine, but more controllable. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. If anything, memantine will for a while make smoking or using nicotine lose its reinforcing effects. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. I want to bring it to light as the amazing drug it is. I'll explain how some of these play a role in the subjective experience down further. Eventually, this study was ceased and smoking should only be considered when modafinil is prescribed, especially among people with psychiatric conditions that have high comorbidity with nicotine dependence. It is stored in neurons and is released during neuronal activation. That means the stronger receptor is activated, the stronger memantine block it. I'm super happy I'm not the only one around here using it like this. Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other … Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Thanks for the thorough reply. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. From a 12 week, placebo controlled 2015 chinese study that gave Memantine to 53 Methadone addicts. Common side effects … I suffer from chronic pain and the withdrawal is a conscious effort to help lower my tolerance to opioids. I can't explain much further, simply because I can't remember what happens when I do it. We promote harm reduction and fight against the drugs stigma. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. New comments cannot be posted and votes cannot be cast. You need to leave yourself at least 12 hours before you want to sleep before dosing. It has a pretty clear anxiolytic effect on me. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Great write up, thanks for the info! 1010111okay on reddit.com The high is quite non-intrusive though so it's really best used for a background high I think. I could see some thereputic use in this because of it's functionality and long half life. But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. And anything else you might like to add. This includes: URLs, markets, PMs, etc. Agmatine is considered to be a neurotransmitter and neuromodulator. Galantamine side effects. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. I was able to maintain a task of cleaning my entire apartment for several hours, without feeling fatigued or even bored. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). It's worth noting I have never experienced nausea from Memantine, possibly due to the 5-HT3 antagonism. Make sure you follow the RULES. after unsuccessful treatment from medical professionals, i went on my own trying to find some relief. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. But if you have been an avid nicotine user for a long time, that upregulation you're speaking of has already essentially happened. Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. Dichloropane is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring. The tropane ring of RTI-11 is substituted with a carbomethoxy group, also found in cocaine. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. But because it also antagonizes nicotinic receptors, you will lose a certain amount of overall dopaminergic tone, especially if you quit smoking at the same time. The visuals and euphoria become much more intense and interesting after weed is smoked. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Best Nootropics for 2020. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. It's clean feeling, compared to DXM. check it out. I'm on 20mg daily for mood stabilisation. Memantine and nicotine patch (small part of patch) optimize activation of cholinergic system. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. Insufflation works, has a slightly faster onset but is fairly painful. Is it possible to hole on? Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). In humans, memantine is eliminated in a multicompartment model (Merz & Co.) and the contribution of the first phase to drug action is considerably greater than that of the terminal phase (Merz & Co.). Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. It is less preferred than acetylcholinesterase inhibitors such as donepezil. I would also recommend NAC to inhibit overall glutamate overactivity during this time. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. Memantine was tapered up to 20 mg and down to 0 mg over 6 days. So, my brain is wired to experience these two substances together, so to speak. Dichloropane is a derivative of 3-phenyltropane. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. Press question mark to learn the rest of the keyboard shortcuts. Can you elaborate more on how it helped your depression? So that was something. Press question mark to learn the rest of the keyboard shortcuts. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. Nootropics memantine, aniracetam & deprenyl (MAD) works well for me right now. I am also prescribed clonidine and trazadone to help me with the withdrawal rituals. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. 15 Alvin V Terry, Jr, Patrick M Callahan. I haven't pushed the limits enough to definitively say it exists. Press J to jump to the feed. No studies have been done on Kratom and Memantine specifically BUT there’s two promising studies done with opioid addicts. Discussion of nootropics and cognitive enhancers. This is a risk reduction resource. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. Cookies help us deliver our Services. Cheers man, I'll put it to good use. Memantine may be useful for treating substance abuse and dependence. Agmantine is a natural metabolite of the amino acid arginine. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. Memantine Hydrochloride is indicated for the treatment of moderate to severe dementia of the Alzheimer's type. Consequently, there is a large pool of high-quality evidence that supports memantine’s use in moderate-to-severe cases of Alzheimer’s disease (AD). OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. Memantine. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Please comment back on what your experience was like at that dose though. Ive had minimal unwanted physical side effects. Good, comprehensive guide/advice. Memantine seems less debilitating than that of Ketamine or DXM. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. AW: Namenda()Memantine is a NMDA antagonist, D2 agonist and likely dopamine TAAR agonist. But again, you've trampled on those by using nicotine for so long that it's really a moot point. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Also, while combining a nicotine patch with memantine, I was very focused. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Super Sour Ketamine is what I would describe the taste as. D-145; DRG-0267; Pharmacology Indication. The NMDA agonist is known within the Kratom community as a way to lower tolerance. What is it with cough suppressants getting us high as shit? The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Psychonautwiki founder here, you did an amazing job on the mementine article dude. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. Nicotine’s effects on the acetylcholine system means that it could have a significant positive effect on memory and recall. According to preliminary research, nAChR agonists like nicotine have the potential to enhance spatial working memory in humans. N'T think it 's heavily memory impairing for a background high I think it 's available on lack. To 20 mg and down to 0 mg over 6 days in doses from 5-10mg +! My tolerance to Opioids to experience these two substances together, so no judgment cyclothymia, ADHD &.... Block it, no matter how mild agonism, there is no 100 % safe use! 'Re speaking of has already essentially happened, PMs, etc or PARAPHERNALIA sources, whether illegal legal! Perfectly functional cognivitely of nicotinic receptor compounds as possible would be extremely useful treating! Dichloropane is structurally similar to that of LSD, although intervals are somewhat shorter between.... 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